Objective: To explore the effect of Six Sigma management on the prevention and treatment of deep vein embolism after percutaneous discectomy. Methods: From January 2019 to January 2020, 60 patients with lumbar disc herniation who underwent percutaneous discectomy at Subei People’s Hospital of Jiangsu Province were selected and randomly divided into experimental group and control group with 30 patients in each group. The control group received routine nursing management measures and the experimental group received Six Sigma management. The effect of Six Sigma management was observed by comparing the Short Form 36 Questionnaire (SF-36) quality of life score, number of complications caused by deep vein embolism and length of stay, etc. between the two groups. Results: After Six Sigma management, the recovery of patients in the experimental group was significantly better than that in the control group. Their quality of life was significantly better, the number of complications was significantly less, the recovery time of lumbar disc was significantly shorter, and the degree of postoperative pain was significantly less. The specific performance was higher SF-36 quality of life score, less complications such as venous intimal injury, blood hypercoagulation, shorter postoperative hospital stay (recovery time), lower Visual Analogue Scale (VAS) pain score, and the differences of four indexes were statistically significant (P<0.05). Conclusion: Six Sigma management can effectively prevent deep vein embolism after percutaneous discectomy in patients with lumbar disc herniation, improve patients’ quality of life, and improve the recovery effect and thus worth popularizing.