Objective: To explore the influence of continuous nursing intervention guided by mind map on the diagnosis and treatment compliance and prognosis of pulmonary tuberculosis patients, so as to provide basis for clinical diagnosis and treatment. Methods: Seventy patients with pulmonary tuberculosis admitted to our hospital from January 2017 to January 2019 were selected for study. According to the method of random number table, all patients were divided into two groups, 35 cases in each group. The control group was given routine nursing intervention, and then the observation group was given continuous nursing intervention guided by mind map on the basis of routine nursing. After six months of intervention, the compliance of diagnosis and treatment, the change of quality of life score, the recovery rate, recurrence rate and nursing satisfaction of the two groups were compared. Results: The compliance rate (71.43%) of the observation group were significantly higher than that of the control group (34.29%), the difference were statistically significant (P<0.05). After the intervention group, the social function, emotional function, physical function and role function score were significantly higher than those in the control group, the difference were statistically significant (P<0.05). The recovery rate (91.43%) of the observation group were significantly higher than that of the control group (71.43%), and the recurrence rate (8.57%) were significantly lower than that of the control group (28.57%), the difference was statistically significant (P<0.05). The nursing satisfaction rate of the observation group (97.14%) were significantly higher than that of the control group (80.00%), the difference was statistically significant (P<0.05). Conclusion: The continuous nursing intervention guided by mind map can significantly improve the compliance of diagnosis and treatment of tuberculosis patients, improve the quality of life of patients, and improve the cure rate.