Objective: To study the effect of goal-directed rehabilitation nursing on neurologic function of hypertensive cerebral hemorrhage in ICU, so as to improve the basis for clinical nursing research. Methods: Fifty patients with hypertensive cerebral hemorrhage from January 2017 to January 2020 in Chuzhou No. 1 People’s Hospital were selected as the study object. All patients were divided into study group (25 cases) and control group (25 cases). The patients in the control group were given routine nursing, mainly including vital signs monitoring, posture change, drug treatment and so on. The patients in the study group were given target-oriented rehabilitation nursing. The neurological deficit, cognitive function and nursing satisfaction of patients’ families were compared between the two groups. Results: Before nursing there were no significant difference the neurological deficit score of the two groups between the two groups (P<0.05). After nursing, the neurological deficit score of the two groups were significantly reduced, and the neurological function score of the study group were significantly lower than that of the control group, the difference was statistically significant (P<0.05). There was no significant difference between the two groups in the mini-mental state examination (MMSE) score before nursing (P<0.05). After nursing, the MMSE scores of the two groups of patients were significantly increased, and the scores of the study group were significantly higher than the control group, the difference was statistically significant (P<0.05). The total nursing satisfaction of the family members in the study group were significantly higher than that in the control group (P<0.05). Conclusion: Objective oriented rehabilitation nursing can effectively improve the neurological function of hypertensive cerebral hemorrhage in ICU, which is worthy of clinical application.