Objective: To explore the short-term effects of hip replacement surgery in patients with perioperative seamless nursing intervention, and provide reference for clinical nursing of patients. Methods: One hundred and ten cases patients who underwent hip arthroplasty in the Hainan Qionghai People’s Hospital from May 2017 to February 2019 were enrolled. According to the simple random number table method, the observation group and the control group were divided into 55 cases each. The control group was given routine perioperative care, and the observation group was given a perioperative risk-free care intervention. After 3 months of follow-up, the Harris score, Visual Analogue Scale (VAS) score, Activity of Daily Living (ADL) score, first time to get out of bed, length of hospital stay, and complication rate were compared between the two groups. Results: There were no significant difference in Harris score between the two groups before operation (P>0.05). The Harris scores of the two groups were significantly improved 1 and 3 months after operation, and the Harris score at 1 and 3 months after operation of the observation group were significantly higher than that in the control group, and the differences were statistically significant (P<0.05). There were no significant difference in preoperative VAS and ADL scores between the two groups before operation (P>0.05). The VAS score at 1 week after operation and the ADL score at 3 months after operation were significantly decreased in the two groups, and the VAS score at 1 week after operation and the ADL score at 3 months after operation were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). The first time of bed-out and hospitalization (21.75±4.05 h, 11.36±1.64 d) in the observation group were significantly shorter than those in the control group (37.94±5.42 h, 15.51±2.18 d), the differences were statistically significant (P<0.05). The complication rate of the observation group (5.45%) was significantly lower than that of the control group (27.27%), and the difference was statistically significant (P<0.05). Conclusion: Perioperative seamless nursing intervention in patients with hip arthroplasty can promote hip joint function rehabilitation, shorten bed rest, hospital stay, reduce postoperative pain, alleviate adverse emotions, reduce complications, and it has the value of promotion and application.