Objective: To evaluate the development of fetal brain in complex congenital heart disease (CHD) by two-dimensional and spectral doppler ultrasound measuring the depth of cerebral sulcus and cerebral blood flow parameters in fetuses with CHD. Methods: A total of 34 cases of abnormal fetuses who underwent ultrasound examination in Baoding No. 1 Central Hospital from June 2016 to June 2018 were selected. Thirty-four normal fetuses with the same gestational age were selected as the normal group. The fetal middle cerebral artery pulsatility index (MCAPI), umbilical artery pulsatility index (UAPI), cerebroplacental ratio (CPR), depth of parietooccipital sulcus, depth of sylvian fissure, depth of calcarine sulcus of the two groups were measured, and the differences of each parameter among the two groups were compared. The neonatal behavioral neurological assessment (NBNA) score was used to evaluate neonatal brain injury, the differences of NBNA score between two groups were compared, the correlation between each parameter and NBNA score were analyzed. Results: There were significantly statistical differences in MCAPI, UAPI, CPR, depth of parietooccipital sulcus, depth of sylvian fissure and depth of calcarine sulcus between CHD group and normal group; The difference of NBNA score between two groups were statistically significant, there was a certain correlation between each parameter and NBNA (P<0.05). Conclusion: Ultrasound can not only make a definite diagnosis of intracardiac malformation of CHD fetus, but also evaluate fetal brain development by measuring cerebral sulcus and cerebral blood flow parameters, thus providing a clinical basis for the prognosis of CHD fetus.