Objective: To study the effect of oxcarbazepine combined with clonazepam on the recovery and complications in patients with epilepsy. Methods: Eighty-nine patients with epilepsy admitted to 983 Hospital of Tianjin Joint Logistics Support Force from March 2017 to March 2019 were selected and their clinical data were analyzed retrospectively. The patients were divided into control group (n=44) and experimental group (n=45) by computer direct insertion sequencing method. The control group was treated with clonazepam, and the experimental group was treated with oxcarbazepine on the basis of the control group. The rehabilitation mechanism and complications of the two groups were observed and compared. Results: The results showed that the frequency of complications and epilepsy in the treatment group was significantly lower than that in the control group, there was no significant difference in quality of life scale for epilepsy-31 (QOLIE-31), Hamilton Anxiety Scale (HAMD) and Hamilton Anxiety Scale (HAMA) between the two groups (P>0.05), the QOLIE-31, HAMD and HAMA scores of the experimental group were significantly higher than those of the control group (P<0.05). Conclusion: Oxcarbazepine and clonazepam are effective in the treatment of epilepsy, it is necessary to use both drugs to treat patients, this is beneficial to reduce the complications and complications of patients, improve their quality of life, reduce their bad mood.