Objective: To analyze the clinical value of thromboelastography and platelet index in patients with cerebral infarction, and to explore the correlation. Methods: A total of 172 patients with cerebral infarction treated in Unsla 904 Hospital from February 2018 to February 2020 were selected. According to the etiology, the patients were divided into a group I, caused by atherosclerosis, and a group II, caused by occlusion of small blood vessels. A total of 172 healthy persons who received medical examinations in our hospital during the same period were selected as the control group. They all received thrombus elasticity chart and platelet index tests, and the difference of index changes between the two groups were compared and the correlation was analyzed. Results: The results showed that the platelet and TEG indexes in group I were significantly different from those in the control group (P<0.05), and there was no significant difference between the group II and the control group (P>0.05). In the platelet indexes, the platelet volume distribution width, the proportion of large platelet and the average platelet volume in group I were higher than those in the control group (P<0.05). There was no significant difference in MA and platelet count among the three groups (P>0.05). Correlation analysis found that with the increase of R value, the mean platelet volume and the proportion of large platelets in thromboelastic graph test of cerebral infarction patients decreased correspondingly, while the higher MA value, the larger platelet volume (P<0.05). Conclusion: R value is negatively correlated with average platelet volume and large platelet proportion. MA value is positively correlated with average platelet volume. To some extent, thromboelastography can reflect platelet index, which can provide reference data for clinical diagnosis and treatment, which is worthy of application and promotion.