To investigate the pathological features, immunohistochemistry and differential diagnosis of solid papillary carcinoma (SPC). The data of 5 patients with SPC were collected, and their pathological features were observed, and the immunohistochemical staining for ER, PR, Her-2, Syn, CgA, Ki-67, p53, CK5/6, p63, CD10 and calponin were retrospectively analyzed. Relevant literature was reviewed. Of the 5 cases, only 1 case was diagnosed because of tumor rupture and discomfort. There was no obvious nipple discharge in all cases. Solid nodular structure and papillary structure were seen under the microscope in all cases. Mucous secretion was seen in two cases, there was one case with mucinous carcinoma. Immunohistochemistry showed that ER and PR were strongly positive, more than 80 percent, in 4 cases, and Her-2 was negative in all patients. Syn was positive in 3 cases, CgA was positive in 1 case. Ki-67 <5% in 4 patients. p53 expression was less than 5% in all patients. SPC is a kind of papillary tumor with unique pathological features, which usually occurs in elderly women with low malignancy, low incidence, and good prognosis.