文章摘要

骨标志物在肿瘤相关骨病中的研究进展

作者: 1褚彦青, 2张匣, 3张谦倩, 4冯和林
1 河北医科大学第四医院手术室，石家庄 050011
2 河北省人民医院血液科，石家庄 050051
3 河北医科大学第二医院妇科，石家庄 050000
4 河北医科大学第四医院骨科，石家庄 050011
通讯: 冯和林 Email: helinfeng0311@163.com
DOI: 10.3978/j.issn.2095-6959.2020.08.042
基金: 河北省自然科学基金(H2019206309).

摘要

外周血或尿液中骨标志物(bone markers，BMs)的测量是现代临床医学骨研究中的重要组成部分。近年来，BMs在临床中的应用明显增加，既可用于骨相关疾病的诊断，又可用于评估干预的效果。尽管肿瘤相关骨病的诊断和治疗策略不断改善，但仍然影响着患者的生活质量，因此在早期识别高危患者是必要的。肿瘤相关骨病影响生理性骨转换，因此BMs测量已广泛用于肿瘤相关骨病的诊断和预后评估。
关键词： 骨标志物；肿瘤相关骨病；骨转换

Research progress in bone markers in tumor-related bone diseases

Authors: 1CHU Yanqing, 2ZHANG Xia, 3ZHANG Qianqian, 4FENG Helin
1 Operating Room, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
2 Department of Hematology, Hebei Provincial People's Hospital, Shijiazhuang 050000, China
3 Department of Gynecology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
4 Department of Orthopaedics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China

CorrespondingAuthor: FENG Helin Email: helinfeng0311@163.com

DOI: 10.3978/j.issn.2095-6959.2020.08.042

Foundation: This work was supported by the Hebei Provincial Natural Science Foundation of China (H2019206309).

Abstract

Measurement of bone markers (BMs) in peripheral blood or urine is an important part of modern clinical medical bone research. In recent years, the use of BMs in clinical practice has increased significantly as they can be used both for the diagnosis of bone-related diseases and for evaluating the effects of interventions. Although the diagnosis and treatment strategies for tumor-associated bone diseases continue to improve, they still affect the quality of life of patients, so it is necessary to identify high-risk patients at an early stage. Tumor-associated bone disease affects physiological bone turnover, so BMs measurements have been widely used for the diagnosis and prognosis evaluation of tumor-associated bone diseases.
Keywords： bone markers; tumor-associated bone disease; bone turnover

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