Objective: To study the clinical effect of rapid rehabilitation nursing in patients undergoing knee replacement surgery. Methods: The case samples were 84 knee arthroplasty patients admitted in our hospital from January 2017 to January 2020. The grouping method was a random number table method, which was divided into 2 groups, namely the study group and the control group. The sample size of the two groups remained the same (n=42). The nursing plan of the control group was routine basic perioperative nursing, and the nursing plan of the study group was rapid rehabilitation nursing. Results: The Visual Analogue Scale (VAS) pain score, knee function score, and knee range score were evaluated after the nursing intervention between the groups. The study group was better than the control group (P<0.05). The postoperative feeding time, bedtime activity time, and length of hospital stay between the evaluation groups were lower in the study group than in the control group (P<0.05), and the nursing satisfaction among the evaluation groups was higher than in the control group (P<0.05). Conclusion: The application of rapid rehabilitation nursing in perioperative nursing of knee replacement patients is effective and worthy of clinical application.