Objective: To investigate the effect of internal plate fixation with different approaches on postoperative fracture healing and functional recovery in patients with middle and upper ulnar fractures. Methods: A total of 97 patients with double upper and middle ulnar radius fractures who underwent surgical treatment in our hospital from June 2015 to February 2017 were randomly divided into treatment group 49 and group B 48. Both patients were treated with trauma after admission. Swelling and other symptomatic treatment, the treatment of group A was fixed by a dorsal single incision approach plate, and the treatment of group B was fixed by a radial and ulnar approach. The clinical efficacy, surgical time, intraoperative blood loss, incision length, fracture healing time, and serum soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) were compared between the two groups. Interleukin 10 (IL-10) and high-sensitivity C-reactive protein (hs-CRP) levels, 5 days after surgery, the patients were assessed for pain with a VAS score, and Hospital for Special Surgery (HSS) scores were used to assess the recovery of forearm function at 2 and 12 weeks Happening. Results: There was no significant difference in the excellent rate, operation time, intraoperative blood loss, fracture healing time, and HSS score of 12 weeks after operation in the two groups (all P>0.05). The length of the incision in group A was significantly shorter than that in group B. The dVAS score was significantly lower than that in treatment group B, and the HSS score was significantly higher than that in treatment group 2 at 2 weeks after operation (all P<0.05); there was no difference in serum sICAM-1, sVCAM-1, IL-10, and hs-CRP levels between the two groups (all P>0.05); there was no significant difference in the incidence of postoperative complications between the two groups (P>0.05). Conclusion: Compared with radial ulnar-side double incision plate internal fixation, dorsal single-incision plate internal fixation for the treatment of double-fracture fractures in the middle and upper segments of the ulnar and radial bone is significantly smaller. Postoperative pain is significantly reduced, and forearm function recovers faster.