Objective: To analyze the application of Propofol combined with fentanyl anesthesia in artificial abortion and its effect on patients’ Th1/Th2 (T helper cell 1/T helper cell 2) cytokine balance. Methods: A total of 90 abortion patients who were admitted to our hospital from January 2018 to April 2019 were selected and randomly divided (a total of 45 samples in each group). The reference group did not use any anesthetic drugs, and the experimental group adopted Propofol Combined fentanyl anesthesia, comparing DBP (diastolic blood pressure), SBP (spontaneous bacterial peritonitis), RR (respiratory rate respiratory rate), HR (heart rate), Th1/Th2 cytokines at different time periods Index, excellent rate of analgesia. Results: In the experimental group, DBP, SBP, RR, HR, serum TNF-α (tumor necrosis factor-a Tumor Necrosis Factor-α) and IL-2 (interleukin-2) factors were all obvious at the end of the operation 2 minutes lower than the reference group, serum IL-10 (interleukin-10) and IL-4 (interleukin-4) factors were significantly higher than the reference group, the experimental group excellent analgesia rate (95.56% ) Was significantly higher than the reference group (13.33%), P<0.05 (all differences were statistically significant). Conclusion: Propofol combined with fentanyl can effectively maintain the stability of vital signs and balance of Th1/Th2 cytokines in patients with artificial abortion, and achieve the ideal analgesic effect, which is worth learning.