Objective: To observe the effect of inhalation induction of sevoflurane with different concentration on emergence agitation in children with adenotonsillectomy. Methods: We selected 90 cases of children with tonsillar and adenoidectomy and divided into S1, S2 and D groups according to the random number table, 30 cases in each group. Patients in groups S1 and S2 were induced by inhalation of sevoflurane at different concentrations until their consciousness disappeared and then transferred to the operating room, followed by intravenous induction and endotracheal intubation. and patients in group D received direct intravenous induction of endotracheal intubation. MAP and HR of patients in the three groups at the time of admission (T0), disappearance of eyelash reflex (T1), intubation (T2) and extubation (T3) were observed. The operation time and recovery time of spontaneous breathing after the operation were recorded for patients in the three groups. The time required for the disappearance of eyelash reflex in the inhalation induction group (S1 group and S2 group) and the score of cooperation degree during the induction of children were recorded. Results: There was no statistical difference in the general information of children in the three groups (P>0.05). Compared with T0, MAP and HR in group D decreased (P<0.05), while MAP and HR in group S1 and S2 increased (P<0.05). Compared with group D, MAP and HR in group T1 increased (P<0.05). There was no significant difference in the scores of operation time, wake time and emergence agitation among the three groups (P>0.05). Compared with group S1, both the disappearance time of eyelash reflex and ICC score of induction period in group S2 were decreased (P<0.05). Conclusion: Inhalation induction with different concentration of sevoflurane has no obvious effect on emergence agitation in children with adenotonsillectomy.