Objective: To study and analyze the clinical value of blood recovery in the transfusion of a large number of allogeneic red blood cell suspensions and the improvement effect on related clinical symptoms. Methods: 100 patients with acute massive hemorrhage admitted in our hospital from August 2016 to August 2019 were selected. By introducing the general data of patients into the computer, the patients were divided into 2 groups: the control group (50 cases, no use of blood recovery for direct transfusion of allogeneic red blood cell suspension) and the study group (50 cases, the suspension was washed by the blood recovery machine before transfusion). The clinical symptoms, blood gas, blood clotting function, body temperature and complications were compared between the 2 groups. Results: after treatment, the improvement of clinical symptoms in the study group was significantly better than that in the control group; 24 hours after infusion, the pH, K+, La in blood gas in the study group showed a significant downward trend, while APTT, FIP and body temperature in patients with coagulation were also significantly improved. The above data were significantly different from those in the control group (P<0.05); at the same time, the study was conducted after infusion. The incidence of complications in the study group was significantly lower than that in the control group (P<0.05). Conclusion: by washing the blood before transfusion of allogeneic red blood cell suspension in the patients with acute massive hemorrhage, the blood gas index and coagulation function can be further improved while ensuring the safety of the patients after transfusion, and the temperature of the patients can be restored to the normal level as soon as possible, which has higher clinical application value.