Objective: To study the efficacy of high-intensity non-invasive ventilation in stable chronic obstructive pulmonary disease patients with type II respiratory failure. Methods: Forty-five patients with chronic obstructive pulmonary exacerbation and type II respiratory failure in our department from September 2017 to September 2018 were selected, after treatment, the disease was still stable with carbon dioxide retention. According to the setting level of non-invasive ventilator inspiratory pressure (IPAP), it is divided into high-intensity non-invasive ventilation (IPAP ≥18 cmH2O) and low-intensity non-invasive ventilation group (IPAP <18 cmH2O). Among them, 28 people in high-intensity group and 17 people in the low-intensity group. Before and after treatment for 1 year, the efficacy in the two groups were compared. Results: After treatment, the two groups of hospitalizations, hospitalization days and modified British medical research council (mMRC) compared with before treatment, the differences were statistically significant (P<0.05), PaCO2 and COPD assessment test (CAT) scores in the high-intensity group were statistically significant (P<0.05), but not statistically significant in the low-intensity group (P>0.05). There were significant differences in the improvement of PaCO2, CAT scores, mMRC, reduction of hospitalizations and hospitalization days compared high-intensity group with low-intensity group (P<0.05). Conclusion: High-intensity non-invasive ventilation in patients with stable chronic obstructive pulmonary disease complicated with type II respiratory failure is better than low-intensity group. Clinically, if patients can tolerate high-pressure levels of non-invasive ventilation, it should be recommended.