糖尿病性骨质疏松症的研究进展
| 作者: |
1倪利华
1 武汉大学中南医院肾病内科，武汉 430071 |
| 通讯: |
倪利华
Email: nilihua2016@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.07.043 |
摘要
糖尿病患者往往合并骨质疏松，这种并发症亦被称为糖尿病性骨质疏松症(diabetic osteoporosis，DOP)。随着我国糖尿病发病率升高，DOP逐渐引起人们的重视。DOP发病机制复杂，可能与胰岛素、胰岛素样生长因子、血糖、晚期糖基化产物形成、胰高血糖素样肽1、微血管并发症、骨髓脂肪组织增多等因素有关。此外，1型和2型糖尿病发生DOP的机制不尽相同。
关键词：
糖尿病；骨质疏松；骨折；发病机制
Research progress of the diabetic osteoporosis
CorrespondingAuthor: NI Lihua Email: nilihua2016@163.com
DOI: 10.3978/j.issn.2095-6959.2020.07.043
Abstract
Osteoporosis is one of the serious complications of diabetes mellitus. These complication also known as diabetic osteoporosis (DOP). As the incidence of diabetes mellitus increases year by year, DOP greatly attracts people's attention. The pathogenesis of DOP is complex, which may be associated with insulin, insulin-like growth factor, blood glucose, advanced glycosylation products, glucagon-like peptide-1, microvascular complications, and the increased bone marrow fat. In addition, the mechanisms of DOP vary from type 1 to type 2 diabetes mellitus.
Keywords：
diabetes; osteoporosis; fracture; pathogenesis