文章摘要

血管生成拟态在乳腺癌中的研究进展

作者: 1,2史珂, 3陈风
1 上海海洋大学水产与生命学院，上海 201306
2 上海市第六人民医院东院普外科，上海 201306
3 上海健康医学院附属第六人民医院东院普外科，上海 201306
通讯: 陈风 Email: chenfengmail@163.com
DOI: 10.3978/j.issn.2095-6959.2020.07.035
基金: 上海健康医学院国家级项目培育专项(SFP-18-20-14-005)。

摘要

血管生成拟态(vasculogenic mimicry，VM)是肿瘤血管新生的途径之一，与经典途径不同，其管样结构并非由内皮细胞而是由癌细胞本身连结形成，为肿瘤的生长和侵袭过程提供血液及营养，并与患者预后密切相关。近些年来，这种全新的肿瘤微循环模式受到了较为广泛的关注。本文将对VM在乳腺癌中的发现及其与乳腺癌干细胞、抗血管生成治疗的研究成果作一综述，并探讨将VM作为癌症治疗靶点的意义以及未来的发展方向。
关键词： 血管生成拟态；乳腺癌；乳腺癌干细胞

Research progress of vasculogenic mimicry in breast cancer

Authors: 1,2SHI Ke, 3CHEN Feng
1 College of Fisheries and Life Science, Shanghai Ocean University, Shanghai 201306, China
2 Department of General Surgery, Shanghai Sixth People’s Hospital East Campus, Shanghai 201306, China
3 Department of General Surgery, Shanghai Sixth People’s Hospital East Campus Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201306, China

CorrespondingAuthor: CHEN Feng Email: chenfengmail@163.com

DOI: 10.3978/j.issn.2095-6959.2020.07.035

Foundation: This work was supported by the National Cultivation Project of Shanghai University of Medicine & Health Sciences, China (SFP-18-20-14-005).

Abstract

Vasculogenic mimicry (VM) is one of the pathways in tumor angiogenesis, which differences from classical pathways. It is connected by cancer cell themselves, not by endothelial cells. VM offers blood and nutrition to the process of tumor progress, and relates to the patients’ prognosis. Recently, this new tumor microcirculation method has received extensive attention. This review aimed to summarize the research progress of the occurrence in breast cancer and breast cancer stem cells with VM and the anti-VM treatment researches. Meanwhile we also discussed the significance of VM to be as a target of breast cancer treatments and the research orientation of it in the future.
Keywords： vasculogenic mimicry; breast cancer; breast cancer stem cell

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