认知行为疗法对帕金森病伴抑郁患者干预效果的Meta分析
| 作者: |
1杨潇潇,
1陈园园,
2孟繁洁
1 天津中医药大学研究生院，天津 301600 2 天津中医药大学中医工程学院，天津 301600 |
| 通讯: |
孟繁洁
Email: mfj127@tjutcm.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2020.07.024 |
摘要
目的：评价认知行为疗法(cognitive behavior therapy，CBT)对帕金森病(Parkinson’s disease，PD)伴抑郁患者的干预效果。方法：计算机检索PubMed，Embase，The Cochrane Library，CNKI，VIP和WanFang中有关CBT对PD伴抑郁患者干预效果的随机对照试验(randomized controlled trial，RCT)。检索时间为建库至2019年6月，按纳入与排除标准进行文献筛选、资料提取和质量评价，采用Revman5.3软件进行Meta分析。结果：共纳入10项研究(570例患者)。Meta分析显示：CBT在长期干预(≥8周)时能够明显改善PD伴抑郁患者的抑郁情绪(SMD=−1.27，95%CI：−1.69，−0.84，P<0.0001]和焦虑情绪(SMD=−0.61，95%CI：−0.97，−0.25，P=0.0008)，提高患者的日常生活活动能力(MD=−5.49，95%CI：−7.47，−3.52，P<0.0001)、运动能力(MD=−5.86，95%CI：−8.19，−3.54，P<0.0001)、生活质量(MD=−6.76，95%CI：−9.04，−4.48)，P<0.0001)；结论：CBT可以改善PD伴抑郁患者的抑郁、焦虑、日常生活活动能力、运动能力以及提高患者生活质量。
关键词：
帕金森病；抑郁；认知行为疗法；焦虑；系统评价
Effect of cognitive behavioral therapy on Parkinson’s disease patients with depression: A Meta-analysis
CorrespondingAuthor: MENG Fanjie Email: mfj127@tjutcm.edu.cn
DOI: 10.3978/j.issn.2095-6959.2020.07.024
Abstract
Objective: To evaluate the effect of cognitive behavioral therapy (CBT) on Parkinson’s disease patients with depression. Methods: Randomized controlled trials (RCTS) were performed on PubMed, Embase, The Cochrane Library, CNKI, VIP and WanFang Data. The retrieval time is from building the database to June 2019. Data extraction and quality evaluation were performed according to inclusion and exclusion criteria. Meta-analysis was performed using Revman5.3 software. Results: A total of 10 studies were included, including 570 patients. Meta-analysis showed that cognitive behavioral therapy (CBT) significantly improved the depression of patients with Parkinson’s disease with depression when long-term intervention (≥8 weeks) (SMD=−1.27, 95% CI: −1.69, −0.84, P<0.0001) and anxiety status (SMD=−0.61, 95% CI: −0.97, −0.25, P=0.0008), and improve the daily life activity ability of patients (MD=−5.49, 95% CI: −7.47, −3.52, P<0.0001), motor ability (MD=−5.86, 95% CI: −8.19, −3.54, P<0.0001), quality of life (MD=−6.76, 95% CI: −9.04, −4.48, P<0.0001). Conclusion: Cognitive behavioral therapy can improve the depression, anxiety, daily activities, motor ability and quality of life of patients with Parkinson’s disease with depression.
Keywords：
Parkinson’s disease; depression; cognitive behavioral therapy; anxiety; Meta-analysis