Objective: To observe the prognosis of patients with allergic rhinitis treated with septoplasty alone and combined with inferior turbinate low-temperature plasma ablation as well as the effect on serum chemokine Eotaxin, intercellular cell adhesion molecule-1 (ICAM-1) and eosinophil cationic protein (ECP). Methods: A total of 96 patients with allergic rhinitis were selected from the hospital and divided into a single group (n=42) and a combined group (n=54) according to the surgical method. The single group were treated with septoplasty and the combined group were treated with septoplasty combined with inferior turbinate low-temperature plasma ablation. The surgical indexes (intraoperative blood loss, surgical time), nasal resistance and inflammatory factors[interleukin 4 (IL-4), interleukin 5 (IL-5)], serum Eotaxin, ICAM-1 and ECP levels before and after surgery, postoperative complete rate of mucosa, complication and curative effect at 1 year after surgery were compared between the 2 groups. Results: There was no significant difference in intraoperative blood loss or surgical time between the 2 groups (P>0.05). After surgery, the nasal resistance, IL-4, IL-5, Eotaxin, ECP and ICAM-1 levels in the combined group were significantly lower than those in the single group (P<0.05). There was no significant difference in the complete rate of mucosa or total incidence of complications between the 2 groups (P>0.05). The curative effect of the combined group was significantly better than that of the single group at 1 year after surgery (P<0.05). Conclusion: Compared with septoplasty alone, septoplasty combined with inferior turbinate low-temperature plasma ablation can achieve better short-term effects in improving nasal airflow in patients with allergic rhinitis, alleviate inflammatory response, and optimize the expression of Eotaxin, ICAM-1 and ECP.