罗库溴铵药效学影响因素的研究进展
| 作者: |
1孙莹,
1岳子勇
1 哈尔滨医科大学附属第二医院麻醉科，哈尔滨 150006 |
| 通讯: |
岳子勇
Email: yueziyong@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.06.039 |
| 基金: | 国家自然科学基金(30772085)。 |
摘要
肌肉松弛是麻醉的常规部分，临床上常用的肌松药物有很多，其中罗库溴铵起效迅速，持续时间长，广泛应用于现代麻醉。其药效学在临床上个体差异较大，原因是其影响因素较多，如性别、年龄、体重指数、体温、缺氧、肝肾功能、pH值、药物、给药方式、心输出量(cardiac output，CO)、补液、昼夜节律、糖尿病等均可引起其药效改变，且可引起术后残余阻滞，导致严重的不良后果。神经肌肉逆转联合神经肌肉监测是降低术后残余阻滞的公认策略。
关键词：
罗库溴铵；影响因素；残余阻滞；肌肉松驰拮抗
Research progress on pharmacodynamics factors of rocuronium
CorrespondingAuthor: YUE Ziyong Email: yueziyong@126.com
DOI: 10.3978/j.issn.2095-6959.2020.06.039
Foundation: This work was supported by the National Natural Science Foundation of China (30772085).
Abstract
Muscle relaxation is a regular part of anesthesia and has important advantages. There are many muscle relaxants commonly used in clinical practice, among them, rocuronium has a rapid onset and long duration and is widely used in modern anesthesia. Its pharmacodynamics differs greatly in clinical practice because of its many influencing factors, such as gender, age, body mass index, body temperature, hypoxia, liver and kidney function, pH, drugs, mode of administration, cardiac output, fluid replacement, circadian rhythm, diabetes, etc. can cause changes in their efficacy, and can cause residual postoperative block, leading to serious adverse consequences. Neuromuscular reversal, together with neuromuscular monitoring, is a well-established strategy for reducing postoperative residual block.
Keywords：
rocuronium bromide; influencial factors; residual block; muscle relaxation antagonism