Objective: To investigate the effect of preoperative management of day surgery based on the best evidence in patients with inguinal hernia. Methods: A total of 252 patients with inguinal hernia who underwent day surgery at Deyang People’s Hospital in 2018 were selected as the subjects of the study. Among them, 115 patients in the control group received routine from January to June, and 137 patients in the experimental group received the preoperative management scheme based on the best evidence from July to December. The temporary cancellation rate of operation, waiting time of operation, awareness of disease and operation-related knowledge, and patient satisfaction were compared between the two groups. Results: The temporary cancellation rate of the patients in the experimental group was lower than that in the control group (4.38% vs 11.30), and the difference was statistically significant (P<0.05). The waiting time before operation in the experimental group was lower than that in the control group [(114.73±23.71) min vs (78.23±26.49) min], and the awareness of disease and surgical knowledge (88.15±10.27 vs 75.71±13.29) and the satisfaction of the patients (96.12±8.03 vs 85.71±14.29) in the experimental group were significantly higher than those in the control group (P<0.01). Conclusion: Pre-operative management based on the best evidence can reduce the temporary cancellation rate of inguinal hernia patients, shorten the waiting time before operation, and improve the level of disease and operation-related knowledge and patient satisfaction. In the future, clinical practice should be further strengthened in order to promote the continuous improvement of preoperative management quality of day surgery.