Objective: To investigate the effect of progressive rehabilitation nursing on the psychological status and quality of life of patients with alcohol-induced mental disorders, and to provide a theoretical basis for the clinical diagnosis and treatment of patients. Methods: A total of 92 cases patients with alcohol-related mental disorders admitted to Beijing Anding Hospital Affiliated to Capital Medical University from January 2018 to March 2019 were selected for the study. The random number table method was used to assigned to an observation group and a control group, with 46 cases in each group. The control group was given routine rehabilitation care to the patient,the observation group gave the patient progressive rehabilitation care based on routine care. The nursing effect of the two groups, the nutritional status, psychological status and quality of life scores of the two groups of patients were recorded at different periods, the nursing satisfaction of the two groups was compared. Results: After 6 months of nursing, the total effective rate of the observation group (95.65%) was significantly higher than that of the control group (73.91%), the difference was statistically significant (P<0.05). Before the nursing, the nutritional status, psychological status and quality of life scores of the two groups were compared, the difference was not statistically significant (P>0.05). After 6 months of nursing, the scores of weight change, nutrition intake, gastrointestinal symptoms, activity and function in the observation group were significantly lower than those in the control group, the difference was statistically significant (P<0.05). The scores of anxiety, depression, sensitivity and hostility in the observation group were significantly lower than those in the control group, the difference was statistically significant (P<0.05). The scores of mental health, physical function, health degree and emotional role in the observation group were significantly higher than those in the control group, the difference was statistically significant (P<0.05). The nursing satisfaction rate of the observation group (95.65%) was significantly higher than that of the control group (71.74%), the difference was statistically significant (P<0.05). Conclusion: The clinical effect of progressive rehabilitation nursing on patients with mental disorders caused by alcohol is significant, can effectively improve the nutritional and psychological status of patients, improve the quality of life of patients, and increase nursing satisfaction, which is worthy of clinical promotion.