微生态制剂联合锌制剂对迁延性腹泻患儿的临床症状和血清相关指标的影响
| 作者: |
1唐晓芳
1 商洛市中心医院儿科二病区，陕西 商洛 726000 |
| 通讯: |
唐晓芳
Email: 2268455886@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.06.024 |
摘要
目的：探讨微生态制剂联合锌制剂疗法对迁延性腹泻患儿临床症状和血清指标的影响。方法：共收集商洛市中心医院儿科2017年1月至2018年12月期间收治的82例迁延性腹泻患儿，年龄1~6岁，随机分为对照组和观察组，两组均41例。所有患儿给予抗病毒、抗感染补液、营养支持等基础对症治疗，对照组给予锌制剂治疗，观察组在对照组基础上联合微生态制剂治疗，持续治疗10 d。比较两组患儿临床症状缓解效果和血清炎症因子、氧化应激指标变化情况，并评估临床治疗效果和安全性。结果：观察组患儿大便性状、大便次数恢复正常时间和腹痛、脱水症状持续时间均显著短于对照组，差异有统计学意义(t=2.545，2.817，2.514，3.519，P<0.05)。两组患儿治疗前血清白介素-6(interleukin 6，IL-6)、白介素-8(interleukin 8，IL-8)、超敏C-反应蛋白(hs-CRP)、一氧化氮(nitric oxide，NO)、丙二醛(malondialdehyde，MDA)比较差异均无统计学意义(P>0.05)，观察组治疗后上述指标均较对照组显著下降，差异有统计学意义(t=9.174，14.099，4.208，5.109，3.293，P<0.01)。观察组无治疗无效病例，治疗总有效率(100%)明显高于对照组(87.80%)，差异有统计学意义(χ2=5.325，P<0.05)。两组均有少数患者出现消化道反应，症状较轻，观察组联合治疗未增加药物不良反应。结论：微生态制剂联合锌制剂可有效缓解迁延性腹泻患儿临床症状，减轻血清炎症和氧化应激反应，且不增加药物不良反应，是一种疗效显著、安全性高的可靠疗法。
关键词：
迁延性腹泻；小儿；微生态制剂；锌制剂；临床症状；炎症因子；氧化应激；疗效；安全性
Effects of microecological agents combined with zinc preparations on clinical symptoms and serum parameters in children with persistent diarrhea
CorrespondingAuthor: TANG Xiaofang Email: 2268455886@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.06.024
Abstract
Objective: To explore the effect of microecological agents combined with zinc preparation therapy on clinical symptoms and serum indicators of children with persistent diarrhea. Methods: A total of 82 children with persistent diarrhea admitted to Shangluo Central Hospital from January 2017 to December 2018, aged 1 to 6 years, were randomly divided into a control group and an observation group, 41 cases in each group. All the children were given basic symptomatic treatment such as anti-virus, anti-infection fluid replacement and nutritional support. The control group was given zinc preparation treatment, while the observation group was treated with micro-ecological preparation on the basis of the control group, all of which lasted for 10 days. The remission effect of clinical symptoms, changes of serum inflammatory factors and oxidative stress indexes were compared between the two groups, and the clinical efficacy and safety were evaluated. Results: The stool characteristics, times of stool returning to normal, duration of abdominal pain and dehydration symptoms in the observation group were significantly lower than those in the control group (t=2.545, 2.817, 2.514, 3.519, P<0.05). The levels of serum IL-6, IL-8, hs-CRP, NO and MDA were not significantly different between the two groups before treatment (P>0.05). The above indexes in the observation group were significantly lower than those in the control group after treatment (t=9.174, 14.099, 4.208, 5.109, 3.293, P<0.01). There were no invalid cases in the observation group, and the total effective rate was 100% higher than 87.80% in the control group (χ2=5.325, P<0.05). There were a few gastrointestinal reactions in both groups, and the symptoms were mild. No side effects were observed in the observation group. Conclusion: Microecological preparation combined with zinc preparation can effectively alleviate the clinical symptoms of children with persistent diarrhea, alleviate inflammation and oxidative stress injury, and do not increase drug side effects. It is a reliable therapy with remarkable curative effect and high safety.
Keywords：
persistent diarrhea; children; microecological agents; zinc preparations; clinical symptoms; inflammatory factors; oxidative stress; efficacy; safety