自拟狼疮方联合甲基泼尼松龙对系统性红斑狼疮患者Th1/Th2细胞因子水平和免疫功能的影响
| 作者: |
1岳峰,
2崔丽敏,
3张珍,
4安巨会,
5刘东海,
1周文花
1 廊坊市人民医院风湿免疫科，河北 廊坊 065000 2 廊坊市妇幼保健中心产筛科，河北 廊坊 065000 3 廊坊市人民医院门诊办公室，河北 廊坊 065000 4 廊坊市人民医院心内科，河北 廊坊 065000 5 廊坊市人民医院皮肤科，河北 廊坊 065000 |
| 通讯: |
岳峰
Email: lfyuefeng@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.06.018 |
| 基金: | 廊坊市科技局(2017013142)。 |
摘要
目的：探讨从中西医结合角度自拟狼疮方联合甲基泼尼松龙治疗系统性红斑狼疮(systemic lupus erythematosus，SLE)临床效果，观察对SLE患者Th1/Th2平衡和免疫功能的影响。方法：将廊坊市人民医院风湿免疫科2015年3月至2019年6月期间收治的78例SLE患者随机分为对照组和观察组，两组各39例。对照组给予甲基泼尼松龙治疗，观察组在对照组基础上自拟狼疮方治疗，比较两组治疗前后SLE疾病活动度(SLE disease activity index，SLEDAI)评分、中医症候积分、Th1/Th2相关细胞因子和免疫指标，并评估两组临床疗效。结果：两组治疗后SLEDAI评分、中医证候积分均显著下降(P<0.05)，观察组治疗后上述指标显著低于对照组，差异有统计学意义(P<0.05)；两组治疗后血清IL-2水平明显升高，IL-4，IL-10水平显著下降(P<0.05)，观察组治疗后血清IL-2水平高于对照组，IL-4，IL-10水平低于对照组，差异有统计学意义(P<0.05)；两组治疗后血清IgG，IgA，IgM均明显降低，补体C3和C4水平显著提高(P<0.05)，观察组治疗后血清IgG，IgA，IgM，C3，C4水平均优于对照组(P<0.05)；观察组临床总有效率92.31%明显高于对照组74.36%，差异有统计学意义(P<0.05)。结论：自拟狼疮方联合甲基泼尼松龙能有效稳定SLE患者病情，调节Th1/Th2平衡和改善免疫功能，起到增益临床疗效的作用。
关键词：
系统性红斑狼疮；自拟狼疮方；甲基泼尼松龙；Th1/Th2平衡；免疫功能
Effect of self-made lupus formula combined with methylprednisolone on Th1/Th2 cytokines and immune function in patients with systemic lupus erythematosus
CorrespondingAuthor: YUE Feng Email: lfyuefeng@126.com
DOI: 10.3978/j.issn.2095-6959.2020.06.018
Foundation: This work was supported by the Langfang Science and Technology Commission Project, China (2017013142).
Abstract
Objective: To investigate the clinical effect of lupus formula combined with methylprednisolone in the treatment of systemic lupus erythematosus (SLE) from the perspective of integration of traditional Chinese and Western medicine, and to observe the effect on Th1/Th2 balance and immune function of SLE patients. Methods: Seventy-eight SLE patients in our hospital from March 2015 to June 2019 were randomly divided into control group and observation group, 39 cases in each group. The control group was treated with methylprednisolone, and the observation group was treated with lupus formula on the basis of the control group. The SLE disease activity index (SLEDAI) score, TCM syndrome score, Th1/Th2 related cytokines and immune indexes before and after treatment were compared between the two groups, and the clinical efficacy of the two groups was evaluated. Results: After treatment, the scores of SLEDAI and TCM syndromes in the two groups decreased significantly (P<0.05), and the above indexes in the observation group were significantly lower than those in the control group (P<0.05); the levels of IL-2 and IL-10 in the observation group were higher than those in the control group, and the levels of IL-4 and IL-10 were lower than those in the control group (P<0.05); after treatment, serum IgG, IgA and IgM in the two groups were significantly reduced, and the levels of C3 and C4 in the complement were significantly increased (P<0.05). The levels of IgG, IgA, IgM, C3 and C4 in the observation group were better than those in the control group (P<0.05); the total clinical effective rate of the observation group was 92.31%, which was significantly higher than that of the control group 74.36% (P<0.05). Conclusion: the self-made lupus formula combined with methylprednisolone can effectively stabilize the condition of SLE patients, regulate the balance of Th1/Th2 and improve the immune function, and play a role in enhancing the clinical efficacy.
Keywords：
systemic lupus erythematosus; self-made lupus formula; methylprednisolone; Th1/Th2 balance; immune function