分化型甲状腺癌伴与不伴慢性淋巴细胞性甲状腺炎的临床对比
| 作者: |
1李浩,
1李华玉,
1唐金涛,
1方大正,
1沈丰,
1胡洪生
1 湖北医药学院附属东风医院甲状腺诊疗中心，湖北 十堰 442000 |
| 通讯: |
胡洪生
Email: huhongsheng2000@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.06.006 |
摘要
目的：回顾性分析伴有慢性淋巴细胞性甲状腺炎(chronic lymphocytic thyroiditis，CLT)的分化型甲状腺癌(differentiated thyroid carcinoma，DTC)与不伴CLT的DTC患者的转移性差异，探讨CLT对DTC生物学行为的影响。方法：收集2010年1月至2017年1月湖北医药学院附属东风医院甲状腺诊疗中心收治的362例DTC患者，根据是否伴有CLT分为两组，132例诊断为DTC伴CLT为实验组，230例DTC不伴CLT患者为对照组。统计两组患者年龄、性别、肿瘤数量、肿瘤直径、肿瘤是否侵犯包膜、患侧中央区淋巴结转移数量的差异并进行对比分析。结果：与对照组相比，实验组DTC伴CLT患者的年龄较小(P=0.017，OR=0.983)，女性占优势(P<0.001，OR=0.810)。肿瘤侵犯甲状腺包膜概率和中央区淋巴结转移的概率显著低于不伴有CLT的DTC，差异均有统计学意义(P=0.036，OR=0.552；P=0.005，OR=0.478)。结论：CLT在DTC转移方面可能起抑制作用，CLT的存在可能将肿瘤限制在原发部位。
关键词：
慢性淋巴细胞性甲状腺炎；桥本氏甲状腺炎；分化型甲状腺癌；炎症；癌症
Clinical comparison of differentiated thyroid carcinoma coexistent with or without chronic lymphocytic thyroiditis
CorrespondingAuthor: HU Hongsheng Email: huhongsheng2000@163.com
DOI: 10.3978/j.issn.2095-6959.2020.06.006
Abstract
Objective: To investigate the effect of chronic lymphocytic thyroiditis (CLT) on the metastasis of differentiated thyroid cancer (DTC), the metastasis difference of differentiated thyroid carcinoma coexistent with or without chronic lymphocytic thyroiditis were analyzed retrospectively. Methods: From Jan 2010 to Jan 2017, 362 DTC patients were divided into two groups by DTC coexistent with or without CLT; 132 patients of DTC coexistent with CLT were the experimental group, 230 patients of DTC coexistent without CLT were the control group. The difference of age, gender, tumor number, tumor diameter, tumor invasion envelope and number of lymph node metastasis in the central area of the affected side between the two groups were statistically analyzed and compared. Results: Compared to the control group, patients of DTC coexistent with CLT were much younger (P=0.017, OR=0.983), and female have numerical superiority (P<0.001, OR=0.810). The probability of tumor invading thyroid capsule and central lymph node metastasis was significantly lower (P=0.036, OR =0.552; P=0.005, OR =0.478). Conclusion: CTL may play an inhibitory role in the metastasis of DTC, perhaps limits in the primary site of the tumor.
Keywords：
chronic lymphocytic thyroiditis; Hashimoto’s thyroiditis; differentiated thyroid carcinoma; inflammation; cancer