Two cases of appendiceal carcinoid were retrospectively analyzed by gross examination, light microscopy and immunohistochemistry. They are typical symptoms of appendicitis before operation in these two cases, and the clinical diagnosis is appendicitis. There is no significant difference of the pathological observation between it and general appendicitis after operation. These two appendices unevenly thicken from the midpiece to the tip, with no obvious space-occupying lesions on the section. Conventionally sampling a piece from the root, middle and tip of the appendix according to Pathology Volume in Clinical Technical Operational Standards, a few scattered heteromorphic cell masses are found in the submucosa, muscular layer and serosa of the appendix. After sampling again, heteromorphic cell mass increase obviously, pathological diagnosis is appendiceal carcinoid with appendicitis. The morbidity of appendiceal carcinoid is low and the rate of missed diagnosis is high. Therefore, pathologists should pay attention to observe the general situation of the appendix when taking samples, and take more samples or even send all the thickened parts, and do not mechanically according to the Pathology Volume in Clinical Technical Operational Standards to take 3 pieces, read the film must be careful, not limited to low times, as far as possible to reduce missed diagnosis.