粪菌移植在炎症性肠病中的价值及其存在的问题
| 作者: |
1王灿,
1王俊,
1张心怡,
1郎婷,
1金黑鹰
1 南京中医药大学第二附属医院肛肠中心(江苏省第二中医院)，南京 210017 |
| 通讯: |
金黑鹰
Email: jinheiying@hotmail.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.05.040 |
| 基金: | 江苏省自然科学基金(BK20191502)；江苏省中医药科技发展计划项目(YB201930)；南京中医药大学第二附属医院(江苏省第二中医医院)院内课题(SEZJJZ2018001)。 |
摘要
粪菌移植(fecal microbiota transplantation，FMT)是治疗炎症性肠病(inflammatory bowel disease，IBD)的一种有效手段，对于激素依赖的溃疡性结肠炎(ulcerative colitis，UC)和克罗恩病(Crohn’s disease，CD)临床有效率和缓解率均优于安慰剂，而且可以促进肠道菌群多样性增加，但是FMT发挥作用的机制、移植细菌的质量控制、移植的方法、次数以及影响FMT细菌定植的因素等均待进一步研究。
关键词：
粪菌移植；炎症性肠病；有效率；治愈率；影响因素
Value and problems of fecal microbiota transplantation in inflammatory bowel disease
CorrespondingAuthor: JIN Heiying Email: jinheiying@hotmail.com
DOI: 10.3978/j.issn.2095-6959.2020.05.040
Foundation: This work was supported by the National Natural Science Foundation of Jiangsu Province (BK20191502), Traditional Chinese Medicine Science and Technology Development Planning Project of Jiangsu Province (YB201930), and The Second Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Second Chinese Medicine Hospital) Foundation(SEZJJZ2018001), China .
Abstract
Fecal microbiota transplantation (FMT) is an effective treatment for inflammatory bowel disease (IBD). It is superior to placebo in clinical efficacy and remission rate for ulcerative colitis (UC) and Crohn’s disease (CD), and it can promote the diversity of intestinal flora. FMT is a very valuable method in the treatment of IBD. Mechanisms, quality control of transplanted bacteria, methods and times of transplantation, as well as factors affecting bacterial colonization of FMT.
Keywords：
fecal microbiota transplantation; inflammatory bowel disease; response rate; remission rate; influence factors