Objective: To explore the influence of mind mapping guided training on the rehabilitation effect of chronic schizophrenia patients in hospital for a long time, and to provide guidance for the management training of patients. Methods: From January 2018 to September 2019, 100 patients with chronic schizophrenia in Shanghai Mental Health Center were selected for study. According to the random number table method, patients were randomly divided into the observation group and the control group, each group of 50 cases. The control group was given routine management training measures, and the observation group was combined with mind map guided training on the basis of the control group. The changes of social function rating scale (SSPI), schizophrenic quality of life scale (SQL) and Herth Hope Scale were compared before and 16 weeks after training. Results: Before training, there was no significant difference in SSPI scores, SQLS scores and Herth Hope Scale scores between the two groups (P>0.05); after training, SSPI scores and Herth Hope Scale scores of the two groups were significantly increased (P<0.05), and the score of the observation group was significantly higher than that of the control group (P<0.05). SQLS scale scores were significantly reduced (P<0.05), and the score of the observation group was statistically significantly lower than that of the control group (P<0.05). Conclusion: Mind mapping guided training can significantly improve the social function and quality of life of chronic schizophrenia patients in long-term hospitalization, and it is worth popularizing.