敏感抗生素联合康妇炎胶囊对慢性盆腔炎患者IL-1，IL-2，CRP，PCT水平的影响及疗效
| 作者: |
1罗晓华,
2杨年,
3李忠勇,
4胥卉苹
1 中国人民解放军5701厂医院妇科，成都 610043 2 四川省人民医院妇产科，成都 610031 3 中国人民解放军5701厂医院中医科，成都 610043 4 成都市温江区人民医院超声科，成都 611130 |
| 通讯: |
罗晓华
Email: 190079916@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.05.018 |
摘要
目的：探讨敏感抗生素联合康妇炎胶囊治疗慢性盆腔炎(chronic pelvic inflammatory disease，CPID)的临床疗效及相关炎症因子水平的变化情况。方法：共选取2016年2月至2019年3月中国人民解放军5701厂医院妇科诊治的160例CPID患者，按照简单随机分组方法分为常规组(n=80)与联合组(n=80)，常规组根据阴道分泌物培养和药敏试验给予敏感抗生素治疗，联合组在对照组基础上给予康妇炎胶囊治疗。借助阴道超声检查测量盆腔包块直径和子宫动脉血流动力参数[搏动指数(pulse index，PI)、阻力指数(resistance index，RI)和收缩期峰值流速(peak systolic velocity，PSV)]，采用酶联免疫吸附试验法(enzyme-linked immunosorbent assay，ELISA)检测血清炎症因子白介素-1(interleukin-1，IL-1)、白介素-2(interleukin-2)、C反应蛋白(C-reactive protein ，CRP)和降钙素原(procalcitonin，PCT)表达水平，并评估治疗效果和安全性。结果：两组治疗后盆腔包块直径和子宫动脉PI，RI均明显降低，PSV明显升高(P<0.05)，且联合组上述指标改善较常规组更为显著，差异有统计学意义(P<0.05)。两组治疗后血清IL-1，CRP，PCT水平明显下降，IL-2水平显著升高(P<0.05)，和常规组比较，联合组血清IL-1，IL-2，CRP，PCT水平改善显著，差异有统计学意义(P<0.05)。联合组临床总有效率(96.25%)高于常规组(86.25%)，差异有统计学意义(P<0.05)。两组不良反应率比较，差异无统计学意义(P>0.05)。结论：敏感抗生素联合康妇炎胶囊能显著减轻CPID炎症反应和改善子宫动脉血流动力学，疗效显著且安全性好，值得临床推广应用。
关键词：
慢性盆腔炎；康妇炎胶囊；敏感抗生素；炎症因子；治疗效果；安全性
Effect of sensitive antibiotics combined with Kangfuyan capsule on levels of IL-1, IL-2, CRP and PCT in patients with chronic pelvic inflammatory disease
CorrespondingAuthor: LUO Xiaohua Email: 190079916@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.05.018
Abstract
Objective: To investigate the clinical efficacy of sensitive antibiotics combined with Kangfuyan capsule in the treatment of chronic pelvic inflammatory disease (CPID) and the changes of related inflammatory factors. Methods: A total of 160 patients with CPID were selected from February 2016 to February 2019. They were randomly divided into a routine group (n=80) and a combined group (n=80). The routine group was treated with sensitive antibiotics according to vaginal secretion culture and drug sensitivity test. The combined group was treated with Kangfuyan capsule on the basis of the control group. Treatment. Pelvic mass diameter and uterine artery hemodynamic parameters pulse index (PI), resistance index (RI) and peak systolic velocity (PSV) were measured by ultrasonography. Enzyme-linked immunosorbent assay (ELISA) was used for detection. Serum levels of inflammatory factors interleukin-1 (IL-1), interleukin-2 (IL-2), C-reactive protein (CRP) and procalcitonin (PCT) were measured, and therapeutic efficacy and safety were evaluated. Results: After treatment, the diameter of pelvic mass, PI and RI of uterine artery were significantly decreased, and PSV was significantly increased in both groups (P<0.05). The improvement of the above indexes in the combined group was more significant than that in the conventional group (P<0.05). After treatment, the levels of serum IL-1, CRP and PCT in the two groups decreased significantly, while the levels of IL-2 increased significantly (P<0.05). Compared with the conventional group, the levels of IL-1, IL-2, CRP and PCT in the combined group improved significantly (P<0.05). The total clinical effective rate of the combined group was 96.25% higher than that of the conventional group 86.25% (P<0.05). There was no significant difference in the rate of adverse reactions between the two groups (P<0.05). Conclusion: Sensitive antibiotics combined with Kangfuyan capsule can significantly alleviate CPID inflammation and improve uterine artery hemodynamics. It is effective and safe and worthy of clinical application.
Keywords：
chronic pelvic inflammatory disease; Kangfuyan capsule; sensitive antibiotics; inflammatory factors; therapeutic effect; safety