The clinicopathological characteristics in 6 cases of malignant solitary fibrous tumor (MSFT) were retrospectively analyzed. Five cases were male, 1 case was female, aged 25 to 69 years old. The neoplasms located in forehead, knee, thigh, supraclavicular and thoracoabdominal wall, measured 1.8–24.5 cm in size. Histologically the tumor was composed of abundant and dense cells, which were separated by rope like collagenous fibrous stroma. The tumor cells were spindle to short-spindle shaped with marked nuclear atypia and increased mitotic activity. The tumor cells arranged in fascicular or swirl pattern. In focal areas, hemangiopericytoma-like structure, coagulative necrosis, focal hemorrhage and invasive margin were presented. Immunohistochemically, the tumor cells were diffusely positive for vimentin, STAT6, CD34, Bcl-2 and CD99; 1 case focally positive for progesterone receptor (PR), all of them were negative for S100, AE1/AE3, EMA, CD117, SOX10, Desmin, smooth muscle actin (SMA) and estrogen receptor (ER), Ki-67 labelling index was 2%–60%. Diagnosis of MSFT mainly relied on its pathological morphology and immunohistochemical profiles. There may be invasive biological behavior in SFT cases with moderate morphology, the tumor should be resected completely as soon as possible with long-term follow-up, beware of malignant transformation. Complete resection of the tumor combined with necessary chemotherapy, radiotherapy or targeted drugs were mostly important to the prognosis of malignant solitary fibrous tumor.