胞外囊泡miRNA在乳腺癌中的研究进展
| 作者: |
1谢长宽,
1王利,
1贾永峰
1 内蒙古医科大学基础医学院，呼和浩特 010110 |
| 通讯: |
贾永峰
Email: yfjia0471@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.04.030 |
| 基金: | 内蒙古自治区肿瘤协同创新培育中心项目(2016ZLXT006，2016ZLXT010)；2019年内蒙古自治区应用技术研究与开发项目：乳腺癌新型标志物筛选鉴定与临床应用的初步研究。 |
摘要
胞外囊泡微小RNAs(microRNAs，miRNAs)是一类19~25个核苷酸的短链非编码RNA，有多效生物学功能，显著调控靶基因表达，影响细胞增殖和凋亡及其他生物学作用。现如今乳腺癌的标志物，如CA125，CA153，CEA，ER，PR，Her2/neu，BRCA1/BRCA2等越来越满足不了临床的需求。因此，对于乳腺癌的早期诊断、治疗和预后等亟需新的生物标志物。胞外囊泡miRNA在肿瘤发生发展、侵袭转移、增殖凋亡、血管生成等过程中均发挥重要作用，对乳腺癌特异性miRNA的鉴定和检出可为早期乳腺癌患者的诊断和减轻疾病负担提供较好的帮助。
关键词：
胞外囊泡；微小RNAs；乳腺癌
Research progress of extracellular vesicle miRNAs in breast cancer
CorrespondingAuthor: JIA Yongfeng Email: yfjia0471@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.030
Foundation: This work was supported by Inner Mongolia Autonomous Region Tumor Collaborative Innovation and Cultivation Center Project (2016ZLXT006, 2016ZLXT010), and Applied Technology Research and Development Project of Inner Mongolia Autonomous Region: Screening and Identification of New Breast Cancer Markers and Preliminary Study of Clinical Application, China.
Abstract
Extracellular vesicle microRNAs (miRNAs) are a family of 19–25 nucleotides in length endogenous noncoding RNAs that can exert pleiotropic biological functions, prominently modulating their target genes expression at post-transcriptional level, affecting cell proliferation and apoptosis. Nowadays, for the biomarker of breast cancer, CA125, CA153, CEA, ER, PR, Her2/neu, and BRCA1/BRCA2 are increasingly unable to meet the clinical needs. Therefore, new biomarkers are urgently needed for early diagnosis, treatment and prognosis of breast cancer. Extracellular vesicle miRNA plays a vital role in tumor development, invasion and metastasis, proliferation and apoptosis, and angiogenesis, etc. As a result, the identification and detection of specific miRNA can provide an excellent opportunity for patients with early stage breast cancer diagnosis and for alleviating disease burden.
Keywords：
extracellular vesicles; microRNAs; breast cancer