肾小球足细胞骨架蛋白的研究进展
| 作者: |
1金英,
1张炯,
1王金泉
1 南京大学医学院附属金陵医院(东部战区总医院)肾脏科，国家肾脏疾病临床医学研究中心，全军肾脏病研究所，南京 210016 |
| 通讯: |
王金泉
Email: doc_wjq@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.04.027 |
| 基金: | 国家自然科学基金(81470944)；国家重点研发计划(2018YFC1312705)。 |
摘要
足细胞是肾小球滤过屏障的重要组成部分，结构独特复杂。足细胞的细胞骨架决定着其形态、结构及对环境刺激的应答能力。足细胞突起部分由初级及次级突触构成。初级突触中的细胞骨架主要有微管与中间丝，次级突触即足突骨架则由肌动蛋白微丝组成。足细胞骨架蛋白受损会导致蛋白尿及肾小球疾病。而与细胞骨架成分有关的肾小球疾病，均可能在此亚细胞结构上寻找到治疗靶点。
关键词：
足细胞细胞骨架；微管；中间丝；肌动蛋白；蛋白尿
Advance of the podocyte cytoskeleton
CorrespondingAuthor: WANG Jinquan Email: doc_wjq@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.027
Foundation: This work was supported by National Natural Science Foundation (81470944) and National Key R&D Program (2018YFC1312705), China.
Abstract
The specific architecture of podocyte cytoskeleton plays a unique role in the glomerular filtration barrier, which regulate the shape, structure and the ability to response environmental stimuli. The processes of podocyte are consisted of primary and secondary parts. A primary processes of podocyte is supported by intermediate filaments and microtubules , while the secondary processes are mainly supported by actin filaments. Even a slight impairment of the cytoskeleton will lead to proteinuria and glomerular diseases. It is possible to find the therapic target from the cytoskeleton proteins in the related glomerular diseases.
Keywords：
podocyte cytoskeleton; microtubule; intermediate filament; actin; proteinuria