上消化道出血患者红细胞分布宽度、谷胱甘肽过氧化物酶、过氧化脂质的变化及其临床意义
| 作者: |
1李海深,
1宗慧丽
1 周口市中心医院急诊内科，河南 周口 466000 |
| 通讯: |
李海深
Email: zkszxyylhs2018@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.04.009 |
摘要
目的：探讨上消化道出血(upper gastrointestinal bleeding，UGIB)患者红细胞分布宽度(red blood cell distribution width，RDW)、血清谷胱甘肽过氧化物酶(serum glutathione peroxidase，Se-GSH-Px)及过氧化脂质(lipid peroxide，LPO)的变化与患者出血量的关系，在治疗前后变化的意义。方法：选取周口市中心医院确诊的110例UGIB患者(UGIB组)、60例健康对象(对照组)，检测两组血红蛋白(hemoglobin，Hb)，红细胞(red blood cells，RBC)，血小板(platelets，HCT)，RDW，Se-GSH-Px及LPO水平；并对比UGIB组不同出血量患者治疗前后上述指标变化。结果：UGIB组患者的RDW，LPO水平显著高于对照组(P<0.05)，UGIB组患者的Hb，RBC，HCT及Se-GSH-Px水平显著低于对照组(P<0.05)。UGIB组轻度出血患者的RDW，LPO水平显著低于中重度出血患者(P<0.05)，轻度出血患者的Hb，RBC，HCT，Se-GSH-Px水平显著高于中重度出血患者(P<0.05)。UGIB患者治疗后的RDW，LPO水平显著低于治疗前(P<0.05)，UGIB患者治疗后Hb，RBC，HCT，Se-GSH-Px水平显著高于治疗前(P<0.05)。结论：UGIB患者RDW，Se-GSH-Px，LPO与其出血量大小有一定的关系，上述指标变化对指导治疗有一定的临床价值。
关键词：
上消化道出血；红细胞分布宽度；谷胱甘肽过氧化物酶；过氧化脂质
Changes of red blood cell distribution width, glutathione peroxidase and lipid peroxide in patients with upper gastrointestinal bleeding and their clinical significance
CorrespondingAuthor: LI Haishen Email: zkszxyylhs2018@163.com
DOI: 10.3978/j.issn.2095-6959.2020.04.009
Abstract
Objective: To investigate the red blood cell distribution width (RDW), serum glutathione peroxidase (Se-GSH-Px) and lipid peroxide (LPO) in patients with upper gastrointestinal bleeding (UGIB) and the amount of bleeding in patients, the significance of changes before and after treatment. Methods: A total of 110 UGIB patients and 60 healthy subjects diagnosed in Zhoukou Central Hospital were selected as a UGIB group and a control group, respectively. Hemoglobin (Hb), red blood cells (RBC), platelets (HCT), RDW, Se-GSH-Px, and LPO levels were detected in the 2 groups. The above indicators in patients with different bleeding volume in the UGIB group were compared before and after treatment. Results: The levels of RDW and LPO in the UGIB group were significantly higher than those in the control group (P<0.05). The levels of Hb, RBC, HCT and Se-GSH-Px in the UGIB group were significantly lower than those in the control group (P<0.05). In the UGIB group, the RDW and LPO levels in patients with mild-bleeding were significantly lower than those in patients with moderate- to severe-bleeding (P<0.05); the levels of Hb, RBC, HCT and Se-GSH-Px in patients with mild-bleeding were significantly higher than those in patients with moderate to severe-bleeding (P<0.05). RDW and LPO levels of UGIB patients after the treatment were significantly lower than those before the treatment (P<0.05). Hb, RBC, HCT, Se-GSH-Px levels in the UGIB patients were significantly higher than those before the treatment (P<0.05). Conclusion: The RDW, Se-GSH-Px and LPO in UGIB patients have a certain relationship with the amount of bleeding, the changes of the above indicators has certain clinical value for guiding treatment.
Keywords：
upper gastrointestinal bleeding; red blood cell distribution width; glutathione peroxidase; lipid peroxide