A patient with stage IV non-small cell lung cancer (NSCLC) was admitted to the Respiratory Ward 1 of Shanxi Cancer Hospital. A 50-year-old male, developed irritating cough and sputum in early October 2012 without obvious inducement. Positron emission tomography-computed tomography (PET-CT) showed carcinoma of the upper lobe of the right lung, metastasis of enlarged lymph nodes in the right locking area, mediastinum and right hilum. Multiple bone destruction throughout the body. Pathology (right lung biopsy): adenocarcinoma. Denaturing high performance liquid chromatography (DHPLC): EGFR19 exon mutation. At the first line, pemetrexed disodium sodium combined with cisplatin was given for 6 cycles of systemic chemotherapy, PFS 8 months; second line gifitinib, PFS 42 months; the third line continued to take gefitinib orally PFS 4 months; oral AZD9291, PFS 11 months; five lines to gefitinib and apatinib, PFS 2 months. Right upper lung wedge resection was performed on the sixth line. Postoperative pathology showed BRAF V600E mutation and cranial metastasis. Pemetrexed disodium + cisplatin systemic chemotherapy was given for two cycles. Droplet digital PCR T790M (+), seven-line oral oxitinib combined with pemetrexil monotherapy for two cycles, and the efficacy was evaluated as PR. Currently, oxitinib has been taken orally, during follow-up.