Primary melanoma of the parotid gland is a rare clinical case. At present, only some cases were reported at home and abroad. This article reported one case admitted to Huanggang Central Hospital in recent years. The patient was 49 years old. The painless package under the right ear was more than 1 year old. In the past six months, the package gradually increased. Then, it was increasing rapidly, with the squiggle on the right side, CT examination showed that 3.7 cm × 1.9 cm of flaky soft tissue density in the right parotid gland area. The general examination showed a 2.5 cm hard area in the parotid gland, with a grayish red section. Under microscopy, the tumor was located in the parotid gland. The tumor cells were arranged in a slice, island shape, and glandular shape. There were a large number of thick fiber intervals. The tumor cells grew invasively into the parotid gland, and some tumor cells formed a pseudo chrysanthemum cluster around the angiogenesis. Flak hemorrhage and necrosis could be seen visibly, small cystic cavitys were formed, and more thin walls, and small blood vessels, and the formation of tumor supositories in some vascular vessels were found. The tumor cells were small, the size was relatively consistent, and the plasma cells were alike. A few coarse melanin particles could be seen inside and outside the tumor cells. Immunographic markers HMB45, Melan-A, CD146, SOX10, S-100, vimentin were all expressed positive, CK7, 34ΒE12, P63, calponin, CK, CEA were all expressed negatively, and the Ki-67 proliferation index was about 30%. Primary melanoma of the parotid gland is a rare malignant tumor. It’s diagnosis needs to combine clinical characteristics, pathological morphology and immune phenotype.