Objective: To explore the correlation between thyroid hormone, 25-(OH)D3 levels and nutritional indicators in maintenance hemodialysis patients. Methods: Seventy-two patients with maintenance hemodialysis received and treated in our hospital from January 2018 to February 2019 were enrolled in the study group; In addition, another 60 health check-up were selected in our hospital during the same period, and the patients were selected as the control group. The levels of thyroid hormone, 25-(OH)D3 and nutritional indicators were measured in two groups, and the correlation between thyroid hormone and 25-(OH)D3 levels and nutritional indicators was analyzed. Results: The levels of total triiodothyronine (TT3), free triiodothyronine (FT3), 25-(OH)D3, seralbumin (ALB), pre-albumin (PA) and total protein (TP) in the study group were significantly lower than those in the control group (P<0.05). There was no significant difference in thyroid-stimulating hormone (TSH) and globulin (GLOB) between the two groups (P>0.05). Among 72 patients with maintenance hemodialysis, there were 10 cases with 25-(OH)D3 levels >30 ng/mL, 51 cases with 25-(OH)D3 levels ranging from 15 to 30 ng/mL, and 11 cases with 25-(OH)D3 levels <15 ng/mL. The levels of ALB, PA and TP in patients with different 25-(OH)D3 levels were significantly different (P<0.05). There was no correlation between thyroid hormone and ALB, PA, TP and GLOB (P>0.05). 25-(OH)D3 was positively correlated with ALB, TP, PA (P<0.05), and there was no correlation with GLOB (P>0.05). Conclusion: Maintenance hemodialysis patients generally have thyroid hormone reduction, vitamin D deficiency or deficiency, and poor nutritional status, and the patient's vitamin D level is positively correlated with the patient’s nutritional index.