骨肉瘤中环状RNA的研究进展
| 作者: |
1何鹏,
1周幸,
1许斌
1 中国人民解放军东部战区总医院骨科，南京 210008 |
| 通讯: |
许斌
Email: xubinnz@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.02.029 |
| 基金: | 国家自然科学基金青年科学基金项目(81802693)；南京军区医疗卫生科技基金(15DX019)。 |
摘要
环状RNA(circular RNAs，circRNAs)是一种特殊的内源性的闭合环状结构的调控RNA，可作为miRNA的“分子海绵”、基因转录和表达调控因子等形式发挥作用，从而调控疾病的发生和发展。近几年研究发现：circRNAs在骨肉瘤细胞与正常细胞中的表达出现差异，部分表达差异的circRNAs参与骨肉瘤的发生发展及转移耐药过程。CircRNAs有望作为骨肉瘤早期诊断、预后评估的生物标志物，也有望作为抗肿瘤治疗的靶标，具有潜在的临床诊断治疗价值。
关键词：
骨肉瘤；环状RNA；肿瘤标志物；药物抵抗
Recent research on circular RNAs in osteosarcoma
CorrespondingAuthor: XU Bin Email: xubinnz@163.com
DOI: 10.3978/j.issn.2095-6959.2020.02.029
Foundation: This work was supported by the Young Scientists Fund of the National Natural Science Foundation (81802693) and Medical Health Science and Technology Project of Nanjing Military Area Command (15DX019), China.
Abstract
Circular RNA is a special kind of endogenous closed and circular structure of RNA. Circular RNA, as the unique regulator of RNA that might regulate the miRNA serving as the miRNA “sponge” molecules and the gene transcription and expression factors, plays a vital role in the occurrence and development of diseases. In recent years, a huge number of literatures confirmed that circRNAs were differentially expressed in osteosarcoma (OS) and normal tissue, some of which were involved in the pathological process of OS by regulating the cells proliferation, invasion, metastasis, apoptosis and drug resistance. More and more evidences revealed that circRNAs might been used as the potential novel biomarker for diagnosis, prognosis prediction and treatment target of osteosarcoma.
Keywords：
osteosarcoma; circRNAs; tumor biomakers; chemoresistance