Objective: To systematically review the efficacy of sodium potassium magnesium calcium and glucose injection on postpartum hemorrhage in cesarean section. Methods: CNKI, Wanfang and VIP database, PubMed, Web of Science, Embase were searched. Randomized controlled trials (RCTs) which sodium, potassium, magnesium, calcium and glucose injection for after cesarean section were included. The clinical symptom remission rate and endoscopic cure rate were used as the outcome index. Meta-analysis was performed on the included literatures. Results: A total of 4 Chinese RCTs were included involving 683 patients. Results of Meta-analysis showed that: The blood loss 2 hours after operation in the sodium potassium magnesium calcium and glucose injection group was lower than that in the sodium lactate rlinger injection group, and the difference was statistically significant (WMD =−56.79, 95% CI: −69.76 to −43.82, P<0.00001, medium level evidence). The blood loss 24 h after operation in the sodium potassium magnesium calcium glucose injection group was lower than that in the sodium lactate ringer injection group, and the difference was statistically significant (WMD =−119.75, 95% CI: −141.10 to −98.40, P<0.00001, medium level evidence). Conclusion: Sodium potassium magnesium calcium glucose injection can effectively prevent postpartum hemorrhage in cesarean section. But multiple center studies are required to validate those conclusions.