Toll样受体4与肾纤维化的关系研究进展
| 作者: |
1宋学萍,
1梁娟,
1王颖娥,
1黄强,
1刘东
1 中国人民解放军联勤保障部队第九四〇医院重症医学科，兰州 730050 |
| 通讯: |
刘东
Email: 386748801@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.01.024 |
| 基金: | 甘肃青年科学基金项目(81600700)。 |
摘要
肾纤维化是大多数慢性肾脏疾病进展至终末期肾病的基本病理改变，其发病过程受到多种信号通路的调节。肾纤维化过程以持续炎症为特征，包括炎性细胞浸润和细胞因子分泌。Toll样受体4(Toll-like receptor-4，TLR4)信号分子是介导肾脏炎症及纤维化的重要桥梁，可通过核因子-κB(nuclear factor-kappa B，NF-κB)激活炎性因子大量释放而造成肾纤维化。TLR4在肾纤维化中发挥重要作用。
关键词：
Toll样受体4；肾纤维化；核因子-κB
Research progress on the relationship between Toll-like receptor 4 and renal fibrosis
CorrespondingAuthor: LIU Dong Email: 386748801@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.01.024
Foundation: This work was supported by the Gansu Youth Science Fund Project, China (81600700).
Abstract
Renal fibrosis is the basic pathological change of most chronic kidney diseases progression to end-stage renal disease. The pathogenesis is regulated by various signaling pathways. The renal fibrosis process is characterized by persistent inflammation, including inflammatory cell infiltration and cytokine secretion. Toll-like receptor 4 (TLR4) signaling molecule is an important bridge mediating renal inflammation and fibrosis, which can cause renal fibrosis by activating the release of inflammatory factors by nuclear factor-kappa B (NF-κB). TLR4 plays an important role in renal fibrosis.
Keywords：
Toll-like receptor4; renal fibrosis; nuclear factor-kappa B