Objective: To investigate the incidence and risk factors of medical adhesive-related skin injury (MARSI) in patients with colon cancer undergoing chemotherapy and indwelling peripherally inserted central catheter (PICC), to construct a risk scoring model of MARSI, and verify its validity. Methods: Data were collected from patients with colon cancer who were treated in Guangdong Hospital of Traditional Chinese Medicine from January 2015 to December 2018 by convenient sampling. Risk assessment system was established by logistic regression analysis, and receiver operating characteristic curve (ROC) analysis was used to verify the validity of the scoring model. Results: A total of 264 patients with colon cancer were enrolled in this study. Among them, 88 patients suffered from MARSI (33.3%), 49 (31.0%) in the model group and 39 (36.8%) in the validation group. Female, age >60 years, allergic history, radiotherapy history and albumin <35 g/L were risk factors of MARSI (P<0.05). Total score of the scoring system was 0–32, of which <5 was low risk, 5–15 was medium risk, and >15 was high risk. ROC results showed that the area under the curve of the modeling group was 0.830, and the area under the curve of the verification group was 0.823, with statistical significance (P<0.05); when the truncation value was 6.5, the Yoden index of the two groups reached the highest. Conclusion: There was a good predictive effect in this risk scoring model constructed at the first time, and can be used for screening the risk of MARSI in patients with colon cancer after PICC catheterization.