Objective: To investigate the clinical value of multi-phase dynamic contrast enhanced CT in the diagnosis and differential diagnosis of early stage renal clear cell carcinoma (ccRCC). Methods: The clinical data and imaging data of 52 ccRCC patients admitted to our hospital were collected and retrospectively analyzed. The enhancement degree and enhancement mode of 52 ccRCC patients in plain scan, corticomedullary phase, renal parenchymal phase and excretory phase in I–II stage patients were compared and analyzed. The results of operation or pathological biopsy were used as the criteria to compare the diagnostic value between plain CT scan group and three-stage dynamic enhanced CT scan group. Results: There was no significant difference in the plain scan group between I and II ccRCC (P>0.05). The CT values(HU)of phase II ccRCC were all higher than those of phase I CCRCC in corticomedullary phase, renal parenchymal phase and excretion phase (P<0.05). Homogeneous enhancement is more common in stage I ccRCC, while heterogeneous enhancement is more common in II phase ccRCC. In addition, 39 patients were accurately diagnosed accurately by CT plain scan, the accurate diagnosis rate was 75%, which was significantly lower than the 98.08% (51/58) of the three-phase dynamic contrast-enhanced scan (P<0.05). Conclusion: In early ccRCC, three-phase dynamic contrast-enhanced spiral CT scanning is valuable for the stage identification. There are significant differences in the degree and mode of enhancement between phase I and phase II ccRCC, which can be used to assist in preoperative staging and treatment options. Compared with unenhanced scans, three-phase dynamic enhanced CT scan presented higher diagnostic accuracy for early stage ccRCC.