酒精性脂肪肝合并幽门螺杆菌感染患者颈动脉内膜中层厚度与炎性、氧化应激因子的相关性
| 作者: |
1王敏,
1周源,
1李常伟,
1周泽伟,
1刘慧
1 重庆市大足区人民医院消化内科，重庆 402360 |
| 通讯: |
周源
Email: 845223997@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.12.023 |
摘要
目的：探讨酒精性脂肪肝(alcoholic fatty liver disease，AFLD)合并幽门螺杆菌(Helicobacter pylori，Hp)患者血清中炎症和氧化应激因子与颈动脉内膜中层厚度(carotid intima-media thickness，CIMT)的关系。方法：选取2018年1月至2019年2月于重庆市大足区人民医院门诊检查及住院的168例男性患者，AFLD合并Hp感染患者为A组，AFLD患者为B组，Hp感染患者为C组，两种病症均无记为D组。颈部超声测量各组双侧CIMT，检测各组血脂、血糖(glucose，GLU)、肝功能指标、炎症及氧化应激因子水平，分析CIMT与各指标的相关性。结果：A组CIMT显著增厚且发生率提高(P<0.05)，患者BMI、血液中总胆固醇(TC)，三酰甘油(TG)，ApoA1，ApoB，丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)及γ-GT均显著高于对照组(P<0.05)。A组白介素6(IL-6)、C反应蛋白(C-reactive protein，CRP)水平明显升高，丙二醛(malondialdehyde，MDA)、超氧化物歧化酶(superoxide dismutase，SOD)水平降低，与D组相比，差异有统计学意义(P<0.05)。AFLD合并Hp感染患者CIMT与年龄，BMI，TC，TG，IL-6，CRP均呈显著正相关(P<0.05)，与MDA，SOD呈负相关(P<0.05)。结论：年龄，BMI，TC，TG，IL-6，CRP及MDA，SOD与AFLD合并Hp感染患者CIMT均呈显著相关，而相关程度可能跟疾病所处的阶段有关。
关键词：
酒精性脂肪肝；幽门螺杆菌；颈动脉内膜中层厚度；炎症；氧化应激
Correlation between carotid intima-media thickness and inflammatory and oxidative stress factors in patients with alcoholic fatty liver complicated with Helicobacter pylori infection
CorrespondingAuthor: ZHOU Yuan Email: 845223997@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.12.023
Abstract
Objective: To investigate the relationship between serum inflammatory, oxidative stress factors and carotid intima-media thickness (CIMT) in patients with alcoholic fatty liver complicated with Helicobacter pylori (Hp) infection. Methods: A total of 168 male patients who were examined and hospitalized in our hospital from January 2018 to February 2019 were selected as the research objects. Patients with alcoholic fatty liver disease complicated with Hp infection were recorded as group A, patients with alcoholic fatty liver disease were recorded as group B, and patients with Hp infection was recorded as group C, neither of which was recorded as group D. CIMT of bilateral common carotid artery in each group was detected by cervical ultrasound, and the levels of blood lipid, blood glucose, liver function, inflammation and oxidative stress factors in each group were detected, and the correlation between CIMT and the indicators was analyzed. Results: In group A, CIMT was significantly thickened and the incidence was increased (P<0.05). BMI, TC, TG, ApoA1, ApoB, ALT, AST and γ-GT in the patients were significantly higher than those in the control group (P<0.05). The levels of IL-6,CRP in group A were significantly higher than that in group D (P<0.05), while the levels of MDA, SOD were lower than that in group D (P<0.05).Patients with alcoholic fatty liver disease complicated with Hp infection showed significant positive correlation with age, BMI, TC, TG, IL-6 and CRP (P<0.05), and negative correlation with MDA and SOD (P<0.05). Conclusion: Age, BMI, TC, TG, IL-6, CRP and MDA, SOD were significantly correlated with carotid intima-media thickness in patients with alcoholic fatty liver complicated with Hp infection, and the degree of correlation might be related to the different stages of the disease.
Keywords：
alcoholic fatty liver disease; Helicobacter pylori; carotid intima-media thickness; inflammation; oxidative stress