Objective: To explore the clinical effect of intramuscular effect (KT) combined with joint mobilization in the treatment of patients with post-stroke shoulder pain (HSP). Methods: Fifty patients with shoulder pain after stroke were selected, according to the random number table method, it was divided into treatment group and control group, both groups were treated with joint mobilization. The treatment group added intramuscular effect treatment on this basis. Before treatment, after 4 weeks of treatment, the visual analogue scale (VAS), modified Barthel index score (MBI), Fugl-Meyer scale (FMA-UE), and PROM scale were used to evaluate the efficacy of the two groups. Results: After 4 weeks of treatment, the MBI, FMA-UE, and ROM scores of the two groups were significantly higher than those before treatment (P<0.05), and the VAS scores were significantly lower than those before treatment (P<0.05), but the comparison between groups, treatment group The scores of MBI, FMA-UE and ROM increased significantly compared with the control group, and the difference was statistically significant (P<0.05). The VAS score of the treatment group was significantly lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The clinical efficacy of intramuscular effect and joint mobilization in the treatment of post-stroke shoulder pain is better than that of simple joint mobilization. The combination therapy has certain clinical value.