Objective: To observe and evaluate the effect of Bu Shen Tongluo prescription on bone density and bone metabolism markers in postmenopausal osteoporosis patients. Methods: Sixty cases of postmenopausal osteoporosis patients admitted to the outpatient department of the Third People’s Hospital of Nantong City from December 1, 2016 to March 30, 2017 were selected and randomly divided into the experimental group with BSTL and the control group with alendronate sodium, 30 cases in each group. All patients were given calcineol D (600 mg, 1 tablet per day) for a course of 3 months. During the observation period, no other Chinese and western drugs for osteoporosis were used. All patients’ general information, lumbar L1–L4 bone mineral density (BMD), T value, blood Ca, blood P, alkaline phosphatase and osteocalcin were detected and recorded before and after treatment, and statistical analysis was performed. Results: After the treatment for 3 months, BMD and T value, blood calcium and blood phosphorus levels in the experimental group increased significantly (P<0.05), alkaline phosphatase and osteocalcin, type I tropocollagen molecules n-terminal propeptide (PINP) levels were significantly lower (P<0.05), two groups of estradiol, calcium/creatinine (urine), type I collagen cross-linking carboxyl terminal peptide (CTX) comparing is no statistical significance (P>0.05). Conclusion: Tonifying kidney and tonifying collaterals can improve bone density, reduce serum calcium and phosphorus loss, and improve bone metabolism