Objective: To investigate the correlation between clinicopathological factors and prognosis in children’s peripheral neuroblastic tumors. Methods: The age, sex, location, clinical stage, pathological type, mitosis karyorrhexis index (MKI), Ki-67 index, treatment and prognosis of peripheral neuroblastic tumors in 119 cases were collected. Then Kaplan-Meier survival curves were drawn, with the Log-rank χ2 test and Cox regression model were used to explore the factors that may influence the prognosis of patients. Results: There were 72 boys and 47 girls with an average age of 28.07 months and an average survival time of 48.74 months. Univariate analysis showed that age, location, clinical stage, Ki-67 index and treatment were associated with prognosis. While multivariate analysis showed that clinical stage and treatment were independent prognostic factors (P<0.05). Conclusion: Peripheral neuroblastic tumors, which are common in pediatric patients, usually have a high mortality rate. Early diagnosis and clear staging, combining with appropriate treatments result from comprehensive examinations, may have a certain clinical significance for improving the prognosis of pediatric patients.