血清CA153水平与2型糖尿病患者肾功能的相关性
| 作者: |
1许爱华,
1雷玉华
1 恩施土家族苗族自治州中心医院内科心血管病中心，湖北 恩施 445000 |
| 通讯: |
雷玉华
Email: huayulei_0319@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.12.013 |
| 基金: | 国家自然科学基金(81260192)；恩施州科技计划项目(E20180003)。 |
摘要
目的：探讨血清糖类抗原153(carbohydrate antigen 153，CA153)与2型糖尿病患者肾功能的关系。方法：纳入180例符合条件的2型糖尿病患者，使用肾小球滤过率(estimated glomerular filtration rate，eGFR)评估肾功能状态。结果：2型糖尿病患者血清CA153水平与血肌酐(r=0.213，P=0.004)，空腹血糖(r=0.203，P=0.005)，糖化血红蛋白(r=0.163，P=0.026)呈正相关，与eGFR(r=−0.238，P=0.002)呈负相关。多元回归分析结果表明，血清CA153水平与eGFR显著相关(beta=0.297，P<0.001)。结论：2型糖尿病患者中，CA153水平与eGFR呈负相关。因此CA153可能成为评估2型糖尿病患者肾功能状态的生物标志物。
关键词：
糖类抗原153；2型糖尿病；肾功能
Correlation between serum CA153 level and renal function in patients with type 2 diabetes mellitus
CorrespondingAuthor: LEI Yuhua Email: huayulei_0319@126.com
DOI: 10.3978/j.issn.2095-6959.2019.12.013
Foundation: This work was supported by the National Natural Science Foundation (81260192) and Science and Technology Project of Enshi Tujia and Miao Autonomous Prefecture (E20180003), China.
Abstract
Objective: To investigate the relationship between serum carbohydrate antigen 153 (CA153) and renal function in patients with type 2 diabetes mellitus. Methods: A total of 180 eligible patients diagnosed with type 2 diabetes mellitus were enrolled. The renal function was assessed by estimated glomerular filtration rate (eGFR). Results: Serum CA153 levels were positively correlated with serum creatinine (r=0.213, P=0.004), fasting blood glucose (r=0.203, P=0.005) and glycosylated hemoglobin (r=0.163, P=0.026), while negatively correlated with eGFR (r=0.238, P=0.002). Multivariate regression analysis showed that serum CA153 levels were significantly correlated with eGFR (beta=0.297, P<0.001). Conclusion: Serum CA153 levels were negatively correlated with eGFR in patients with type 2 diabetes mellitus. Therefore, serum CA153 levels may be a biomarker for evaluating renal function in patients with type 2 diabetes mellitus.
Keywords：
carbohydrate antigen 153; type 2 diabetes mellitus; renal function