雄激素不敏感综合征4例临床病理分析
| 作者: |
1邢澄,
1康小玲,
1廖燕霞,
1张佳立,
1霍雷军
1 广东省妇幼保健院病理科，广州 511400 |
| 通讯: |
邢澄
Email: santa_fe@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.11.038 |
摘要
通过分析4例雄激素不敏感综合征(androgen insensitivity syndrome，AIS)的临床病例特点、鉴别诊断、治疗及预后，综合复习相关文献。4例患者均为完全型AIS，年龄15~33岁，其中2例存在性腺肿瘤，均位于腹腔，肿瘤类型包括精原细胞瘤、Sertoli-Leydig细胞肿瘤(高分化)及纤维瘤(1例)，Sertoli细胞腺瘤(1例)。所有患者均行性腺切除手术。AIS的诊断需要结合临床特征、影像学检查及染色体核型分析等方面综合考虑。
关键词：
雄激素不敏感综合征；性腺肿瘤；免疫组织化学；鉴别诊断
Clinicopathologic analysis of 4 cases of androgen insensitivity syndrome
CorrespondingAuthor: XING Cheng Email: santa_fe@163.com
DOI: 10.3978/j.issn.2095-6959.2019.11.038
Abstract
The clinicopathologic pathological features, differential diagnosis, treatment and prognosis of 4 analysis cases of androgen insensitivity syndrome (AIS) were investigated and the related literature was reviewed. All 4 patients were complete AIS (CAIS) aged 15 to 33. Two patients were diagnosed with gonadal tumor, all in the abdominal cavity and the tumor types included seminoma, well differentiated Sertoli-Leydig cell tumor and fibrothecoma (1 case) and Sertoli cell tumor (1 case). All patients were performed gonadectomy. The diagnosis of AIS needs combined consideration of clinical features, imaging examination and chromosome karyotype analysis.
Keywords：
androgen insensitivity syndrome; gonadal tumor; immunohistochemistry; differential diagnosis