Objective: To investigate the application of rapid rehabilitation nursing in laparoscopic focal clearance and fenestration for affected side fallopian tube in treatment of ectopic pregnancy patients. Methods: A total of 90 patients admitted to our hospital from October 2017 to October 2018 for the treatment of ectopic pregnancy were selected as the objects. They were divided into a control group (n=45) and an observation group (n=45) according to even-odd order of admission. The control group was given routine nursing for intervention, while the observation group was given rapid rehabilitation nursing for intervention. The surgical indexes, psychological status[Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD)], incidence of complications and patients’ satisfaction were compared between the two groups. Results: After intervention, there was no significant difference in operation time or intraoperative blood loss between the two groups (P>0.05). In the observation group, the first time of anal exhaust, the time of urinary tube removal and the time of hospitalization were shorter than the control group, and the time of getting out of bed was earlier than the control group (P<0.05). After intervention, HAMA and HAMD scores of the observation group were significantly lower than those of the control group (P<0.05). After intervention, incidence of complications in the observation group was significantly lower than that in the control group (8.89% vs 26.67%) (P<0.05). After intervention, scores of service attitude, service content and personnel quality, and total score in the observation group were significantly higher than those in the control group (P<0.05). Conclusion: The application of rapid rehabilitation nursing is significant in laparoscopic focal clearance and fenestration for affected side fallopian tube in treatment of ectopic pregnancy patients, which can improve negative emotion, reduce incidence of complications, improve patients’ satisfaction and promote prognosis.