不同病因肝内胆管癌行肝切除术预后与年龄的关系
| 作者: |
1李昊昱,
1陆丽华,
1夏勇,
1沈锋,
1李俊
1 上海东方肝胆外科医院肝外四科，上海 200438 |
| 通讯: |
沈锋
Email: shenfengenbh@sina.com 李俊 Email: lijundfgd1@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.11.012 |
| 基金: | 国家自然科学基金(81772531)；上海市优秀学术/技术带头人计划(19XD1425000)；上海市科学技术委员会医学引导项目(18411968900)。 |
摘要
目的：探讨不同病因的肝内胆管癌(intrahepatic cholangiocarcinoma，ICC)患者行肝切除术预后与年龄之间的关系。方法：对东方肝胆外科医院2004至2010年期间行R0切除术的606名肝内胆管癌患者进行分析。将患者分为乙肝相关组(HBV-ICC，n=456)，结石相关组(stone-ICC，n=75)及其他病因组(other-ICC，n=85)。按年龄分为青年组(<40岁)、中年组(40~60岁)及老年组(>60岁)。分别对不同年龄段不同病因的患者进行生存分析对比。结果：青年组及老年组两种病因的总生存期差异无统计学意义(P=0.236，P=0.151)；而中年组两种病因总生存期差异有统计学意义(P=0.002)；青年组及老年组两种病因的复发率差异无统计学意义(P=0.169，P=0.126)，而中年组复发率差异有统计学意义(P=0.003)。结论：在不同年龄段的患者中，不同病因肝内胆管癌切除术后的生存及复发均存在差异。
关键词：
肝内胆管癌；病因；年龄
Relationship between age and outcome of intrahepatic cholangiocarcinoma of different causative factors
CorrespondingAuthor: SHEN Feng Email: shenfengenbh@sina.com
DOI: 10.3978/j.issn.2095-6959.2019.11.012
Foundation: This work was supported by the National Natural Science Foundation (81772531), Program of Shanghai Academic/Technology Research Leader (19XD1425000)
Abstract
Objective: To evaluate the impact of different causative factors of intrahepatic cholangiocarcinoma (ICC) on disease outcome related to age. Methods: Date of 606 consecutive patients undergoing R0 liver resection for ICC at the Eastern Hepatobiliary Surgery Hospital between 2004 and 2010 were analyzed. These patients were divided into a hepatitis B virus-related (HBV-ICC, n=456), a hepatolithiasis-related (stone-ICC, n=75), and an other etiologies-related (other-ICC, n= 85) ICC groups. Patients were classified into 3 groups by age bracket; younger group (<40 years), middle-aged group (40–60 years), and elderly group (above 60 years). Results: The differences of overall survival in the younger group and the elderly group were all not statistically significant (P=0.236, P=0.151), while in the middle-aged group it was significant (P=0.002). Recurrence in the younger group and the elderly group showed no significant difference (P=0.169, P=0.126), but existed significance in the middle-aged group (P=0.003). Conclusion: In different age-related groups, outcome of different causative factors of ICC exist differences.
Keywords：
intrahepatic cholangiocarcinoma; causative factors; age