腹腔镜卵巢囊肿剔除术对卵巢囊肿患者卵巢功能、血清抗苗勒管激素、抑制素B的影响及其意义
| 作者: |
1施佳艳,
1陈鹃,
1陈琪珍
1 上海市第一人民医院宝山分院妇产科，上海 200940 |
| 通讯: |
施佳艳
Email: xczhjys@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.11.009 |
摘要
目的：探讨腹腔镜卵巢囊肿剔除术(laparoscopic ovarian cyst removal，LOCR)治疗卵巢囊肿对患者卵巢功能、血清抗苗勒管激素(anti-Mullerian hormone，AMH)、抑制素B(inhibin B，INHB)水平的影响。方法：选取上海市第一人民医院2015年1月至2017年6月收治的手术治疗的卵巢囊肿患者114例的临床资料进行分析。根据手术方法分为A组(n=53)、B组(n=61)，A组采用LOCR手术治疗，B组采用开腹手术治疗；同时选取60例正常妇女测量相关指标作为对照组；对比3组的卵巢功能、血清AMH、INHB、卵泡刺激素(FSH)、雌激素(E2)、促黄体生成素(LH)水平。结果：术后3个月，与B组比较，A组卵巢体积差异无统计学意义(P>0.05)，A组窦卵泡数目多于B组(P<0.05)。A组和B组的卵巢体积及窦卵泡数目均小于对照组(P<0.05)。术前，两组A，B组血清AMH、INHB水平比较，差异无统计学意义(P>0.05)；术后3个月，A组血清AMH水平均高于B组(P<0.05)，INHB低于对照组(P<0.05)；术前，两组血清FSH，E2，LH水平比较，差异无统计学意义(P>0.05)；术后3个月，A组血清FSH，LH水平均低于B组(P<0.05)，A组血清E2水平高于B组(P<0.05)。结论：LOCR治疗卵巢囊肿较开腹手术更加有利于术后卵巢功能的恢复，避免血清AMH，INHB水平在术后大幅下降。
关键词：
腹腔镜卵巢囊肿剔除术；卵巢囊肿；卵巢功能；抗苗勒管激素；抑制素B
Effect of LOCR on ovarian function, serum AMH and INHB in patients with ovarian cyst and its significance
CorrespondingAuthor: SHI Jiayan Email: xczhjys@126.com
DOI: 10.3978/j.issn.2095-6959.2019.11.009
Abstract
Objective: To investigate the effects of laparoscopic ovarian cyst removal (LOCR) on ovarian function, serum anti-Mullerian hormone (AMH) and inhibin B (INHB) levels in patients with ovarian cysts. Methods: Clinical data of 114 patients with ovarian cysts treated surgically in our hospital from January 2015 to June 2017 were analyzed. The patients were divided into group A (n=53) and group B (n=61). Group A was treated with LOCR and group B was treated with open surgery. At the same time, 60 normal women were selected as a control group. The ovarian function, serum AMH, INHB levels, FSH, E2 and LH were compared among the three groups. Results: Three months after the operation, there was no significant difference in ovarian volume between group A and group B (P>0.05), and the number of sinus follicles in group A was more than that in group B (P<0.05). The ovarian volume and the number of sinus follicles in group A and B were smaller than those in control group (P<0.05). Before the operation, there was no significant difference in serum AMH and INHB levels between the two groups (P>0.05). Three months after the operation, serum AMH level in group A was higher than that in group B (P<0.05), and INHB was lower than that in the control group (P<0.05). Before the operation, there was no significant difference in serum FSH, E2 and LH levels between the two groups (P>0.05). Three months after operation, serum FSH and LH levels in group A were lower than those in group B (P<0.05), and serum E2 levels in group A were higher than those in group B (P<0.05). Conclusion: LOCR treatment of ovarian cysts is more conducive to the recovery of ovarian function after the surgery than open surgery, avoiding the significant decrease of serum AMH and INHB levels after the surgery.
Keywords：
laparoscopic ovarian cyst removal; ovarian cyst; ovarian function; anti-Mullerian hormone; inhibin B